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Nefazodone, Ruoxinlin (Ansofaxine), & Mental Health Links

Updated: 12/3/22

Nefazodone Information

Tapering from Antidepressants

How Sleep is Effected by Nefazodone & Antidepressants

General Info on Nefazodone from Drugs.com

History of Nefazodone and General Info. from Wikipedia

PDR for Nefazodone - Reference that doctors use. Very Extensive.

Info Page on Nefazodone from Drugbank.

Explains how Nefazodone's effects change as you get older.

Nefazodone Package Insert

Teva's Press Release on Nefazodone Return

Teva's Nefazodone Page, there is a link in here to the approval letter the FDA sent to Teva.

FDA Drug Shortage site for Nefazodone

Wikipedia Page on SNDRI's and goes into ones that are in clinical trials. Some of this information is not up to date. Some of the meds listed in trials have had their trials canceled.

Wikipedia Page on Ruoxinlin (Ansofaxine) an upcoming SNDRI.

Results of Phase III clinical trials on Ansofaxine - Apr. 2021

This is a very comprehensive article that references multiple studies on tapering. Some of it applies to antipsychotics (but those can be used for depression or anxiety), but I think it applies to antidepressants too. It talks about rapid withdrawal causing movement disorders (tardive dyskinesia).

This talks about akathisia which some members got from tapering too fast or going cold turkey. It has some of the meds used for treatment.

An article on protracted withdrawal.

Going off antidepressants, withdrawal, tapering, and half-lifes.  As a note:  Nefazodone is 2-5 hours & 3.6 days.

Extensive detailed info about tapering and withdrawal.

Very large forum about tapering and creating micro doses.  Has individual sections for specific meds.

Discontinuation symptoms of Nefazodone.

Relapse after stopping antidepressants, can occur months after tapering off.

An article on how antidepressants are used to treat insomnia.

Antidepressants Effect on Sleep.

Effects of Nefazodone on Sleep Architecture.

Study of Sleep on Nefazodone vx. Paroxetine.

Nefazodone Patient Review Sites

Nefazodone Reviews on Everyday Health

Medications that can cause obstructive sleep apnea due to weight gain.  Antidepressants and antipsychotics are included in the list.

Nefazodone Reviews on Drugs.com

Talks about properly being tapered off antidepressants and how to minimize potential withdrawal effects.

Ruoxinlin (Ansofaxine) Information

Home Page of the manufacturer of Ruoxinlin (Ansofaxine), Luye Pharma

Results of Phase II clinical trials on Ansofaxine - Nov. 2021

Pipeline Status of Ansofaxine (LY03005)

Nefazodone Reviews on Webmd

Nefazodone Reviews at Ask A Patient

Effects of Nefazodone on quality of sleep for PTSD.

Nefazodone Reviews at CVS, reviews are at the bottom of the page.

Mental Health and Wellbeing

Ansofaxine, A New Hope for Depression

'Playing the Odds'  Antidepressant Withdrawal

'Playing the Odds'  Antidepressant Withdrawal - Revisited

Tapering SSRI's

Efficacy of Nefazodone

Subreddit Page for Nefazodone and Ansofaxine

Ruoxinlin Press Release on approval in China. Gives overview of the medication.

Press Release on Launch of Ruoxinlin in China.

A psychiatrist explains tapering and what doctors are taught in school

Research Articles

Future blood test that could tell if an antidepressant is going to work after taking it for a couple of weeks.

New treatment for depression called SAINT.

Research results on nefazodone for treatment of major depressive disorder.

Study on Nefazodone as a migraine preventative.

Study on the effects of lavender on anxiety.

Potential new medication called BNC210 that is different than SSRI's, SNRI's etc.

Discounts Prescription Sites

A very extensive site on different mental health subjects.  Many of the articles here are written by doctors.

This article talks about General Anxiety Disorder (GAD) and different types of treatments.

How to build mental resilience and tips for improving your mental health.

Hypothyroidism and effects on mental health.  As a note Nefazodone can change the effectiveness of some thyroid medications.

Seasonal Depression and Light Therapy.

GoodRX --  also provides links to the patient assistance programs for the very expensive specialized drugs.  This is usually based on income, but if you qualify you may receive your medication at no expense.

Prescription discounts from Verywell Health.

This site provided the best prices for Walgreens.

This site provides discounts for local independent pharmacies.

Handouts that psychiatrists hand out to patients.  It goes beyond medications such as exercise, sleep, diet, and mindfullness.  It has recommended books, apps, audio files, light therapy, etc.

Root cause of Depression and Anxiety may lead to new treatments.

How to manage treatment resistant depression.

Why Doctors are trying to reduce the use of Benzodiazepines

Benefits and risks of Benzos.

Benzo withdrawal and symptoms.

Foods that are good for depression and anxiety.

Research on the percentage of patients who experience sexual side effects on antidepressants, Nefazodone was the best at only 8%.

PH94B a New Nasal Spray for Social Anxiety Disorder

Interesting Statistics about reviews of antidepressants.

Pipeline Status for new mental illness medications - Jan. 2022.

Stellate Ganglion Blocks for treatment of psychiatric disorders.

13 Blood tests to get done if you have depression.

Research on Reinstatement, note that the theme is more research is needed.

A list of antidepressants that can cause liver damage.

Nefazodone isn't the only antidepressant the can cause liver damage.

Sexual Dysfunction caused by Antidepressants

The American Psychiatric Association and the FDA have advised against using Genesite testing.

Extensive info on Pipeline of new Mental Illness meds.  Part 1

Extensive info on Pipeline of new Mental Illness meds.  Part 2

Another Discount Site: IntelligentRx

Autoimmune Disorders and Inflammations Effect on
Mental Illness

Infection, Autoimmune disease linked to depression.

Autoimmune Disease and Mental Health.

Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses.

The concept of depression as a dysfunction of the immune system.

Depression in Autoimmune Diseases.

Role of Inflammation in Depression and Treatment Implications.

Autoimmune Diseases and Psychotic Disorders.

Study on Nefazodone as a treatment for psychotic unipolar and bipolar depressions vs amitriptyline and haldol.

Miscellaneous Sites

Drug interaction checker from Drugs.com

Drug Interaction checker from Webmd

Youtube video on how drug tablets are made.

Explains how long medications are effective after their expiration dates.

Explains how brand name and generic medications are the same.

This is the online version of the PDR that doctors use. It has drug interactions, how combining meds can enhance certain aspects of the med, etc. This is really comprehensive.

List of Supplements that interact with Benzos and SSRI's

Interaction Between Herbs and Medications

Find an independent local pharmacies based on location.

Company started by Mark Cuban that buys generics directly from manufacturers and charges cost + 15% + $3 pharmacy fee + $5 shipping. No insurance, but their price may be better than using your insurance. Nefazodone isn't currently on it, but keep checking.

Really interesting site that shows how many prescriptions were written for each medication for medicare patients.  The data is for the year 2019.

Site that shows what kind of payments a doctor has received.  From pharmaceuticals, for research, etc.

This site allows you to see what prescriptions and how many a doctor has written for Medicare patients. The data is from the year 2019.  This may help if you are looking for a doctor that will prescribe a certain medication.

Nefazodone as a treatment for bipolar disorder.

Myth: Antidepressants work by numbing all emotions.

Zuranolone New medication trial results for treatment of MDD

Sage Pharmas upcoming medication Zuranolone

FDA Approves SAINT Neuromodulation Device

Prescribing Antidepressants in 2022

Study on Single dose of Psilocybin for depression

Antidepressant Efficacy

Study on measuring serotonin release in the brain

Artificial sweetener linked to Increased Anxiety

Neurotransmitters effected by Nefazodone

Disclaimer:  This is an informational site only.  It is not intended as medical advice.  Please consult your doctor.

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